Leah’s research focuses on emotional and behavioral dysregulation across the life course. Through her work, Leah seeks to build knowledge about the origins, mechanisms, and outcomes of self-regulation difficulties. Her interests center on the development of mental-health difficulties including substance use disorders, antisocial behavior, suicide, and self-harm; as well as physical-health difficulties including age-related diseases. Leah’s research is organized around two central questions: (1) How do genes and environments combine to shape the emergence and course of emotional and behavioral dysregulation? and (2) How can we improve identification and intervention among at-risk youth, to prevent and mitigate the outcomes of dysregulation in later life? She pursues these questions using genetically-informative, longitudinal, and nationwide administrative-register study designs.